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Conflicts of interest None declared. Funding sources This study was funded by Laboratoires Vichy, France. Journal of the European Academy of Dermatology and Venereology.

J Eur Acad Dermatol Venereol. Published online Jul 7. Bouloc , 1 E. Moga , 4 B. Chadoutaud , 5 and B. Author information Article notes Copyright and License information Disclaimer. Bouloc, Email: moc. Corresponding author.

Received Jan 12; Accepted May 9. Abstract Introduction Acne in adult women is an increasing reason for dermatological consultations. Methods Subjects were randomized to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone.

Conclusion In conclusion, the tested skincare combined with a fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne. Introduction Acne in adult women is an increasing reason for dermatological consultations. Methods A prospective, randomized study was conducted in Spain and Poland in compliance with local regulatory and ethical requirements. Table 1 Treatment groups regimens.

Open in a separate window. Figure 1. Figure 2. Quantitative characterization of the lipid profile A total of 70 complete skin lipid profiles 23 from Group A, 23 from Group B and 24 from Group C were available for quantitative skin lipid assessment. Figure 3. Then there are the user reviews. In August , Differin boasted more than 32, five-star ratings on Amazon, 5. Clearly, there's a pattern here: People who use Differin think it's amazing, and it has the expert stamp of approval for clearer, blemish-free skin, too.

But it's also a prescription-strength formula. As a result, there are a few things to consider before adding it to your nighttime routine. Here are six things everyone should know about this powerful way to prevent pimples. Retinoid is a term that includes all vitamin A derivatives, such as retinol, retinaldehyde, retinoic acid, and naphthoic acid derivatives. Adapalene is the latter. So while there are many over-the-counter retinol creams on the market, Differin is not one.

Both retinols and adapalene are derived from vitamin A, a powerhouse anti-ager that increases cell turnover, but retinol is much weaker than its prescription counterpart and can take longer to deliver noticeable results, explained Ava Shamban, MD , a Beverly Hills dermatologist and founder of SKIN FIVE.

Shamban said. Adapalene was the only retinoid available over the counter, as of July ; and you needed a prescription for its stronger form, adapalene 0.

The chemical formula of adapalene is C28H28O3 and its molar mass is The most common side effects of adapalene include photosensitivity, irritation, redness, dryness, itching, and burning.

These are mild and common side effects that tend to decrease over time. Severe allergic reactions are rare for this medicine. Benzoyl peroxide is an organic compound having the chemical formula C 14 H 10 O 4.

There are two major applications of this compound; as medication and as an industrial chemical. The molar mass is However, it tends to undergo decomposition. Since it is OTC, it is not as strong as prescription retinoids in comparison, but it is still potent enough to provide a number of skin benefits. Retinol gets into the deeper layers of the skin and boosts elasticity and collagen production.

Therefore, it is helpful for treating fine lines and acne. Retinoids and retinol are not exactly the same thing, but rather, retinol is a type of retinoid! But what are retinoids? Simply put, they are derivatives of vitamin A and they are useful in combating acne and photo-aging through their anti-inflammatory and comedone-destroying properties.

Retinoids can be classified into different generations with retinol and tretinoin belonging to the first generation and adapalene in the third generation. Both retinol and adapalene are retinoids, but they are not the same thing. Adapalene is stronger and more potent than retinol because it contains active retinoic acid. Retinol is not as potent and is lower in strength.

Between the four of these skincare ingredients, benzoyl peroxide is the one outlier that is not a retinoid. Adapalene, tretinoin, and retinol all fall under the retinoid umbrella. However, in terms of accessibility, tretinoin is the outlier because it is available prescription only. Benzoyl peroxide and retinol are over-the-counter, and adapalene in 0. When it comes to side effects, tretinoin causes the most skin irritation and redness.

Adapalene and retinol can can itchiness and redness as well, but it is to a lesser extent than tretinoin. Benzoyl peroxide carries the unique side effect of its ability to bleach clothes and skin. However, we do have some trends based on randomized controlled trials that have been performed. Both of these agents have established efficacy in treating acne, with benzoyl peroxide being useful for killing acne-causing bacteria and retinol exhibiting the comedolytic properties of retinoids.

However, on their own, benzoyl peroxide and retinol tend to be used for mild to moderate acne. More severe acne requires the use of more powerful, prescription-strength topical retinoids such as adapalene and tretinoin.

 

- Differin ou benzac

  This ultimately reduces clogged pores and promotes skin turnover for clearer skin. All women who provided written consent and met the inclusion criteria were randomized at each study site in a 1 : 1 : 1 way to receive for 90 days:. But it's also a prescription-strength formula. Instead, follow Differin with an ultra-rich moisturizer that will calm irritation and deliver much-needed hydration. The American Academy of Dermatology recommended to stop using adapalene during pregnancy.