Looking for: Prednisone for sciatica dosage. Oral steroids in initial treatment of acute sciatica Click here Steroids for sciatica | MDedge Internal Medicine.Prednisone Offers Modest Relief in Sciatica | MedPage Today Study record managers: refer to the Data Element Definitions if submitting registration or results information. Sciatica is most often caused by a herniated disc in the lumbar region of the back and results from inflammation of the nerve roots as they exit the spine. It is a very common cause of back and leg pain, loss of function, and inability to work. Although sciatica is common, the effectiveness of current treatments is limited. Epidural steroid injections ESIs , which can reduce inflammation of the nerve roots, are commonly used to decrease sciatica pain and restore normal function in patients. The exact effectiveness of ESIs, however, is unknown. If inflammation, and not compression, is the main cause of sciatica, it is reasona...